深圳康源久远生物技术有限公司

Shu-Min Liu, Ph. D. (CEO)

  1. Patent: “Long Acting Multi-Specific Molecules and Related Methods”, Patent Pending, US 62/408,865 (2016).
  2. Hong Zhao, Karen Yang, Cliff Longley, Shu-Min Liu, Yixian Zhang, Qing-Hong Dai, Jing Xia, Dechun Wu, Charles Conover (2012) Controlled Release of Proteins Through Releasable PEGylation, presented at the 39th Annual Meeting & Exposition of the Controlled Release Society in Québec City, Canada, July 15-18, 2012.
  3. Liu, SM, Miller, DM, Roberts, RF. (2011) Cloning of genes encoding colicin E2 in Lactococcus lactis subspecies lactis and evaluation of the colicin-producing transformants as inhibitors of Escherichia coli O157:H7 during milk fermentation, J Dairy Sci. 94(3):1146-54.
  4. Ying Gao, Jenny Pak, Shu-Min Liu, Yixian Zhang, Melissa Dumble and Yaming Wu, Stephen Youngster, Lee M. Greenberger (2011) Quantification of locked nucleic acid –based phosphothioate oligonucleotides in tumor tissues by LC/MS/MS, Presented at 2011 AAPS Annual Meeting, Washington DC.
  5. Maoliang Wang, Amartya Basu, Thomas Palm, Jack Hua, Stephen Youngster, Lisa Hwang, Hsien-Ching Liu, Xiguang Li, Ping Peng, Yue Zhang, Hong Zhao, Zhihua Zhang, Clifford Longley, Mary Mehlig, Virna Borowski, Prakash Sai, Manickam Viswanathan, Eun Jang, Gerald Petti, Shu-Min Liu, Karen Yang, and David Filpula (2006) Engineering an Arginine Catabolizing Bioconjugate: Biochemical and Pharmacological Characterization of PEGylated Derivatives of Arginine Deiminase from Mycoplasma arthritidis. Bioconjugate Chem., 17 (6), 1447 -1459.
  6. Amartya Basu, Karen Yang, Maoliang Wang, Shu-Min Liu, Ramesh Chintala, Thomas Palm, Hong Zhao, Ping Peng, Dechun Wu, Zhenfan Zhang, Jack Hua, Ming-Ching Hsieh, John Zhou, Gerald Petti, Xiguang Li, Ahsen Janjua, Magda Mendez, Jun Liu, Clifford Longley, Zhihua Zhang, Mary Mehlig, Virna Borowski, Manickam Viswanathan, and David Filpula (2006) Structure-Function Engineering of Interferon-beta-1b for Improving Stability, Solubility, Po-tency, Immunogenicity, and Pharmacokinetic Properties by Site-Selective Mono-PEGylation. Bioconjugate Chemistry, Volume 17 Issue 3, pp 618 – 630.
  7. Karen Yang, Amartya Basu, Maoliang Wang, Ramesh Chintala, Ming-Ching Hsieh, Shu-Min Liu, Jack Hua, Zhenfan Zhang, John Zhou, Mark Li, Hnin Phyu, Gerald Petti, Magda Mendez, Haleema Janjua, Ping Peng, Clifford Longley, Virna Borowski, Mary Mehlig and David Filpula (2003) Tailoring structure–function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation. Protein Engineering vol. 16 no. 10 pp. 761-770.
  8. Shelton E. Murinda, Shu-Min Liu, Robert F. Roberts, and Richard A. Wilson (1998), Colicinogeny among Escherichia coli serotypes, including O157:H7, representing four closely related diarrheagenic clones. Journal of Food Protection. 61(11): 1431-1438.

  Dechun(David)  Wu, MS/MBA (COO)

ISSUED PATENT and PATENT APPLICATION:

  1. ” Accelerated Hydrolysis System”,Patent Pending, US Serial No. 16/008,201 filed on June 14, 2018, Yuxin Han,Kelly Chen, Dechun Wu.
  2. “Long Acting Multi-Specific Molecules and Related Methods”, WO2018075308 (2018), Liu,  Shumin, Wu, Dechun.
  3. “Multi-Arm Polymeric Conjugates of 7-Ethyl-10-Hydroxycamptothecin for Treatment of Breast, Colorectal, Pancreatic, Ovarian and Lung Cancers” Granted 2013/EP1996208B1, Hong Zhao, Maria Belen Rubio, Sapra Puja, Dechun Wu.
  4. “Process for the Preparation of Polymer Conjugates” Granted 2012/CN101163507B, Dechun Wu. Richard B. Greenwald, Hong Zhao.
  5. “Methods of preparing activated polymers having alpha nitrogen groups” Granted 2012/ EP1988912B1, Dechun Wu, Hong Zhao
  6. “Polymeric Conjugates of Aromatic Amine Containing Compounds Including Releasable Urea Linker” Patent Application US20120289571A1, CN102724967A, EP2519228A2, EP2519228A4, WO2011082368A2, WO2011082368A3, Hong Zhao, Dechun Wu, Snehlata Tripathi, Jing Xia
  7. “Multi-Arm Polymeric Conjugates of 7-Ethyl-10-Hydroxycamptothecin for Treatment of Breast, Colorectal, Pancreatic, Ovarian and Lung Cancers” Granted 2012/US82990892B2, Hong Zhao, Maria Belen Rubio, Dechun Wu, Puja Sapra
  8. “Process for the Preparation of Polymer Conjugates” Granted 2012/EP1848459B1, Dechun Wu. Richard B. Greenwald, Hong Zhao
  9. “Multi-Arm Polymeric Conjugates of 7-Ethyl-10-Hydroxycamptothecin for Treatment of Breast, Colorectal, Pancreatic, Ovarian and Lung Cancers” Granted 2012/CN101420963B, Hong Zhao, Maria Belen Rubio, Sapra Puja, Wu Dechun
  10. “Methods of preparing activated polymers having alpha nitrogen groups” Granted 2012/ US8133707B2, Dechun Wu, Hong Zhao
  11. “Branched Cationic Lipids for Nucleic Acids Delivery System” Patent Application US20110305769A1, CA2742689A1, CN102216462A, EP2350296A1, EP2350296A4, WO2010056403A1, Hong Zhao, Weili Yan, Lianjun Shi, Dechun Wu
  12. “Releasable Fusogenic Lipids for Nucleic Acids Delivery System” Patent Application US20110223257A1, CA2742846A1, CN102215820A, EP2355799A1, EP2355799A4, WO2010057160A1, WO2010057160A9, Maksim Royzen, Lianjun Shi, Dechun Wu, Weili Yan, Hong Zhao
  13. “Releasable Cationic Lipids for Nucleic Acids Delivery System” Patent Application US20110229581A1, CA2742776A1, CN102231952A, EP2364085A1, EP2364085A4, WO2010057155A1, Maksim Royzen, Lianjun Shi, Dechun Wu, Weili Yan, Hong Zhao
  14. “Releasable Polymeric Lipids for Nucleic Acids Delivery System” Patent Application US20110305770A1, CA2742838A1, CN102231950A, EP2362728A1, WO2010057150A1, WO2010057150A8, Lianjun Shi, Dechun Wu, Weili Yan, Hong Zhao
  15. “A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, prodrugs of (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3′,4′:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; anticarcinogenic agents” Granted 2010/US7723351B2, Hong Zhao, Maria Belen Rubio, Dechun Wu, Puja Sapra
  16. “Multi-Arm Polymeric Conjugates of 7-Ethyl-10-Hydroxycamptothecin for Treatment of Breast, Colorectal, Pancreatic, Ovarian and Lung Cancers” Granted 2008/US7462627B2 Maria Belen Rubio, Puja Sapra, Dechun Wu, Hong Zhao
  17. “Activating polyethylene glycol; reacting with multi-functional linking moiety; quenching; deprotecting, neutralization, reacting with biologically active moiety such as drug, polypeptide, protein”Granted 2008/US7365127B2, Dechun Wu. Hong Zhao

 SCIENTIFIC PUBLICATION:

  1. “Controlled Release of Proteins through Releasable PEGylation” World Congress and Expo on Biowaivers and Biosimilars, 2012, Presentation
  2. “Novel Releasable PEG-Conjugates of LNA Antisense Oligonucleotides as Potent mRNA Inhibitors to Cancer Targets” Tides, 2012 poster
  3. "Controlled Release of Proteins Through Releasable PEGylation" Presented at the 39th Annual Meeting & Exposition of the Controlled Release Society in Québec City, Canada, July 15-18, 2012.
  4. “Customized PEG Linkers Improve the Pharmaceutical Properties of Cytotoxic Small MoleculesPEGylation” AACR 2010  poster # 2645
  5. “Novel Releasable PEG-Nanoparticles Enhance Delivery of RNA Antagonist Oligonucleotides in Tumor Cells and in Mice” Poster # 6134, AACR Annual meeting 2009
  6. “Novel PEG-Nanoparticles Enhance Delivery of RNA Antagonist Oligonucleotides in Tumor Cells and in Mice” Abstract # 646, OTS 4th Annual meeting, 2008
  7. “Utility of Customized Target PEG Linkers Delivery of Oligonucleotides Without the Use of Transfection Reagents” Poster, NSTI Nanotech 2008, 2, 372-374
  8. “Novel Prodrugs of SN38 Using Multi-Arm Polethylene Glycol (PEG) Linkers” Bioconjugate Chemistry, 19, No 4, Page 849-859, 2008
  9. “Utility of Customized PEG Linkers for the Delivery of Oligonucleotides without the Use of Transfection Reagents” 2007 AACR-NCI-EORTC. Poster # 957.
  10. “Releasable PEGylation of Mesothelin Targeted Immunotoxin SS1P Achieves Single Dosage Complete Regression of a Human Carcinoma in Mice” Bioconjugate Chemistry, Vol 18, 773-784 (2007).
  11. “EZN-2208, a Novel Polyethyleneglycol-SN38 Conjugate, Improves Pharmacological Properties of SN38 in Mice and Rats” AACR A Meeting, April 14-18, 2007, Poster # 1496.
  12. “EZN-2208, a Novel Polyethyleneglycol-SN38 Conjugate, Has Potent Antitumor Activity in a Panel of Human Tumor Xenografts” AACR Annual Meeting, 2007 Poster # 1494.
  13. “Novel Prodrugs of SN38 Generated by Multi-Arm Poly (ethylene glycol)” 18th.EORTC-NCI-AACR Symposium, Nov. 7-10, 2006, Poster# 154.
  14. “Structure-Function Engineering of Interferon-β-1b for Improving Stability, Solubility, Potency, Immunogenicity, and Pharmacokinetic Properties by Site-selective Mono-PEGylation” Bioconjugate Chemistry, Vol 17, Number 3,  618-630, (2006).
  15. “Poly (ethylene glycol) Prodrugs of the CDK Inhibitor, Alsterpaullone (NSC 705701): Synthesis and Pharmacokinetic Studies” Bioconjugate Chem., Vol.15 1076-1083 (2004).
  16. “Selective Phenolic Acylation of 10-Hydroxy Camptothecin Using Poly (Ethylene Glycol) Carboxylic Acid” Bioorg. Med. Chem. Let, Vol. 13, 577-580 (2003).
  17. “Anticancer Drug Delivery Systems: Multi-loaded N4-acyl poly (ethylene glycol) Prodrugs of Ara-C II. Efficacy in Ascites and Solid Tumors” J. Controlled Release Vol. 79, 55-70 (2002).
  18. “Anticancer Drug Delivery Systems: N4-acyl poly (ethylene glycol) Prodrugs of Ara-C I. Efficacy in Solid Tumors” Journal of Controlled Release, Vol. 79, 41-53 (2002).
  19. “Drug Delivery Systems Based on Trimethyl Lock Lactonization: Poly (ethylene glycol) Prodrugs of Amino-Containing Compounds” Journal of Medicinal Chemistry, Vol. 43, Number 3, 475-487 (2000).
  20. “Drug Delivery of Anticancer Agents: Water Soluble 4-poly (ethylene glycol) Derivatives of the Lignan, Podophyllotoxin Journal of Controlled Release, Vol. 61, 281-294 (1999).”
  21. “Camptothecin-20-PEG Ester Transport Forms: the Effect of Spacer Groups on Anti-tumor Activity” Bioorganic & Medicinal Chemistry, Vol. 6, 551-562 (1998)
  22. “Computer Application to Subtraction Spectra in Mass Spectra” Journal of Chinese Mass Spectrometry Society, Vol.6 (3) 29 (1985).

Yvonne Wen, Ph.D. (CSO)

  1. Yu Wen, Allison Isola, Gian-Paul Vidal, Jiadong Li, Byeong-Seon Jeong, Maung Naing Shan, Yong Lin, Karine Cohen-Solal, Suzie Chen, and James Goydos. Activation of Metabotropic Glutamate Receptor 1 Increases the Amount of Pro-oncogenic Proteins in Melanoma-derived Exosomes. Submitted and under review.
  2. Yu Wen, Jiadong Li, Maung Naing Lin Shan, Suzie Chen, Howard Kaufman, James Goydos,.  Tumor Associated Macrophages Contribute to GRM1 Induced Immunosuppression in Melanoma.  Submitted and under review.
  3. Allison Isola, Kecinn Eddy, Yu Wen, James Goydos and Suzie Chen, Exosomes released by Metabotropic Glutamate Receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness. Submitted and under review.
  4. Yu Wen, He N. Xu, Zhenwu Lin, Lisa Privette Vinnedge, Susanne Wells, Lin Z. Li. DEK oncogene influences optical redox state of breast cancer cells. In preparation for submission
  5. Zhenwu Lin, He N. Xu, Lijun Zhang, Yu Wen, Yunhua Wang, Tony R. Lin, Joanna Floros, Lin Li. Differential PGC1α expression among redox subpopulations of mouse xenografts of aggressive human breast cancer. The 45thAnnual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT), Aug 19-23, 2017, Halle, Germany.
  6. Gian-Paul Vidal, James Goydos, Yu Wen. GRM1/IL-8/CXCR1 Signaling Could Lead to Increased Stemness in Melanoma. Accepted for 2015 Annual Retreat on Cancer Research in New Jersey. May 20, 2015, Piscataway, NJ.
  7. Yu Wen, Jasmine Koo, Michelle DeLeon, Jiadong Li, Maung Naing Lin Shan, Xin Yu, Janice M Mehnert, Yong Lin, Suzie Chen, James S Goydos. Metabotropic Glutamate Receptor 1 Regulates Pro-oncogenic Exosome Production to Promote Tumor Growth, Metastasis, and Angiogenesis in Melanoma. Submitted and under review
  8. Wen Y, Li J, Koo J, Shin S-S, Lin Y, Jeong B-S, Cohen-Solal K , Mehnert JM, Chen S, Goydos JS.  Activation Of Glutamate Receptor GRM1 Enhances Angiogenic Signaling To Drive Melanoma Progression. Cancer Res. 2014 May 1; 74(9):2499-509. PMID: 24491800, PMCID: PMC4008638.
  9. Teh JL, Shah R, Shin SS, Wen Y, Mehnert JM, Goydos J, Chen S. Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor. Pigment Cell Melanoma Res. 2014 Jul; 27(4): 621-9. PMID: 24628914, PMCID: PMC4061214.
  10. Rosenberg SA, Niglio SA, Salehomoum N, Chan JL, Jeong BS, Wen Y, Li J, Fukui J, Chen S, Shin SS, Goydos JS. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Transl Oncol. 2015 Feb;8(1):1-9. doi: 10.1016/j.tranon.2014.11.001. PubMed PMID: 25749171; PubMed Central PMCID: PMC4350641.
  11. Abushahba W, Olabisi OO, Jeong BS, Boregowda RK, Wen Y, Liu F, Goydos JS, Lasfar A, Cohen-Solal KA. Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma. PLoS One. 2012; 7(10):e47312. PMCID: PMC3470581.
  12. N. Semlani, D. Grabell, J. Li, B.S. Jeong, S. Chen, Y. Wen, J. Goydos. Preclinical study targeting metabotropic glutamate receptor (GRM1) angiogenesis pathway. The 2012 Annual Retreat on Cancer Research in New Jersey. May 24, 2012, Piscataway, NJ.
  13. J. M. Mehnert, Y. Wen, N. Semlani, A. R. Tan, John Joseph Wright, Joseph Aisner, James S Goydos. A phase I trial of riluzole and sorafenib in patients with advanced solid tumors and melanoma. Annual Conference of ASCO. May 31-June 5, 2012, Chicago, IL.
  14. J. M. Mehnert, Y. Wen, J. H. Lee, L. Dudek, L. Pruski-Clark, W. Shih, S. Chen, J. S. Goydos. A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor (GRM1) signaling, in advanced melanoma. Annual Conference of ASCO, June 3-7, 2011, Chicago, IL.
  15. Jasmine Koo, Yu Wen, Jiadong Li, Suzie Chen, James Goydos. GRM1over-expression in melanoma cells promotes microvesicle (exosomes) formation which functions in stimulating angiogenesis. 104 Annual Conference of AACR. April 6-10, 2013, Washington, DC
  16. Wen Y, Giardina SF, Hamming D, Greenman J, Zachariah E, Bacolod MD, Liu H, Shia J, Amenta PS, Barany F, Paty P, Gerald W, Notterman D. (2006). GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. Clin Cancer Res. 2006; 12:5951-9.
  17. Chi, O. Z., Barsoum, S., Wen, Y., Liu, X. and Weiss, H. R. 17β-Estradiol Prevents Blood-brain barrier Disruption Induced by VEGF. Horm Metb Res 2004; 36:272-276.
  18. Rohrbaugh, E. Ramos, D. Nguyen, M. Price, Y. Wen and Z-C Lai, Notch Activation of yan Expression is antagonized by RTK/Pointed Signaling in the Drosophila Eye. Current Biology, 2002; 12:1-20.
  19. Wen Y., Nguyen D., Li Y. and Lai Z.-C. The N-terminal BTB/POZ domain and C-terminal sequences are essential for tramtrack69 to specify cell fate in the developing Drosophila eye. Genetics 2000; 156(1):195-203.